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In vitro research have proven that leptin also inhibits testosterone manufacturing instantly at the testes. A selection of epidemiological reports have identified that bone mineral density in the aging male population is positively linked with endogenous androgen concentrations (Murphy et al 1993 Ongphiphadhanakul et al 1995 Rucker et al 2004). Testosterone degrees in younger adult men have been revealed to correlate with bone size, indicating a function in dedication of peak bone mass and security from future osteoporosis (Lorentzon et al 2005). Male hypogonadism has been demonstrated to be a chance element for hip fracture (Jackson et al 1992) and a recent analyze confirmed a superior prevalence of hypogonadism in a group of male individuals with regular age 75 decades presenting with minimal trauma fractures compared to stroke victims who acted as controls (Leifke et al 2005). Estrogen is a nicely regarded determinant of bone density in gals and some investigators have located serum estrogen to be a potent determinant of male bone density (Khosla et al 1998 Khosla et al 2001). Serum estrogen was also located to correlate better than testosterone with peak bone mass (Khosla et al 2001) but this is in contradiction of a additional modern research showing a unfavorable correlation of estrogen with peak bone dimension (Lorentzon et al 2005). Men with aromatase deficiency (Carani et al 1997) or defunctioning estrogen receptor mutations (Smith et al 1994) have been uncovered to have abnormally reduced bone density regardless of ordinary or superior testosterone ranges which additional emphasizes the vital affect of estrogen on male bone density.
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