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In vitro scientific studies have demonstrated that leptin also inhibits testosterone output right at the testes. A range of epidemiological studies have discovered that bone mineral density in the aging male inhabitants is positively involved with endogenous androgen concentrations (Murphy et al 1993 Ongphiphadhanakul et al 1995 Rucker et al 2004). Testosterone degrees in young gentlemen have been proven to correlate with bone measurement, indicating a job in determination of peak bone mass and protection from upcoming osteoporosis (Lorentzon et al 2005). Male hypogonadism has been shown to be a risk element for hip fracture (Jackson et al 1992) and a modern review showed a high prevalence of hypogonadism in a group of male individuals with normal age 75 years presenting with negligible trauma fractures in comparison to stroke victims who acted as controls (Leifke et al 2005). Estrogen is a perfectly recognised determinant of bone density in women of all ages and some investigators have observed serum estrogen to be a solid determinant of male bone density (Khosla et al 1998 Khosla et al 2001). Serum estrogen was also uncovered to correlate far better than testosterone with peak bone mass (Khosla et al 2001) but this is in contradiction of a additional new study displaying a unfavorable correlation of estrogen with peak bone dimensions (Lorentzon et al 2005). Men with aromatase deficiency (Carani et al 1997) or defunctioning estrogen receptor mutations (Smith et al 1994) have been uncovered to have abnormally minimal bone density inspite of normal or higher testosterone levels which further more emphasizes the crucial influence of estrogen on male bone density.
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